Leonard and Sheldon are brilliant physicists - wizards in the laboratory, but socially inept outside of it. Enter beautiful, free-spirited neighbor, Penny, who aims to teach them a thing or two about life.
While Leonard spends his days looking for love, Sheldon is quite content video-chatting with platonic partner Amy Farrah Fowler, or playing Star Trek 3-D chess with their ever-expanding universe of friends, including fellow scientists Koothrappali and Wolowitz, and Wolowitz's wife, the adorable micro-biologist, Bernadette.
01 - The Date Night Variable
On the sixth season premiere, Howard discovers that he can't escape his mother - even in space! Back on earth, meanwhile, Raj turns his existence as a third wheel into an art form.
02 - The Decoupling Fluctuation
When Sheldon learns that Penny is thinking about breaking up with Leonard, he tries to intervene. But Sheldon is no good at keeping secrets. Meanwhile, Howard is being picked on in space by the other astronauts (guest stars PASHA LYCHNIKOFF and MIKE MASSIMINO).
03 - The Higgs Boson Observation
While the pressures of being in space starts to take its toll on Howard, Amy feels threatened when Sheldon hires a young female assistant, Alex (guest star MARGO HARSHMAN).
04 - The Re-Entry Minimization
When Howard returns from space, he doesn't get the hero's welcome he expected. Meanwhile, Game Night turns into a battle of the sexes.
05 - The Holographic Excitation
The gang celebrates Halloween at Stuart's comic book store. Meanwhile Leonard and Penny discover a new spark in their relationship when he seduces her with science. And while Howard can't stop talking about space, it takes iconic astronaut BUZZ ALDRIN (guest starring as himself) to get him grounded again.
06 - The Extract Obliteration
Sheldon's tenuous relationship with renowned scientist STEPHEN HAWKING is threatened by a game of "Words with Friends," while Penny secretly enrolls in a class at the local college.
07 - The Habitation Configuration
Pressured by Bernadette, Howard comes to terms with moving out of his mother's house. Meanwhile, Sheldon, who's caught in the middle of a feud between his "girlfriend" Amy and good friend WIL WHEATON, goes to Penny for advice. Star Trek's LeVAR BURTON guest stars.
08 - The 43 Peculiarity
Howard and Raj try to get to the bottom of why Sheldon disappears every afternoon at 2:45. Meanwhile, Leonard and Penny wrestle with jealousy in their relationship.
09 - The Parking Spot Escalation
When the University reassigns Sheldon's (unused) parking spot to Howard, the ensuing turf battle affects the whole gang.
10 - The Fish Guts Displacement
Sheldon plays nursemaid to a sick Amy, while Howard attempts to bond with his father-in-law (guest star CASEY SANDER) on an upcoming fishing trip.
11 - The Santa Simulation
Sheldon unwillingly revisits some Christmas memories during a lively game of Dungeons and Dragons, while Penny, Bernadette and Amy try to find the perfect girl for Raj when he joins the girls for ladies night.
12 - The Egg Salad Equivalency
Sheldon is accused of sexual harassment at the University and winds up dragging Leonard, Raj and Howard into the fray. Southland's REGINA KING guest stars as the University's Director of Employee Relations.
13 - The Bakersfield Expedition
While the guys take a road trip to a comic book convention in Bakersfield dressed as characters from Star Trek: The Next Generation, Leonard's car is stolen. Meanwhile, the girls stay home and try to appreciate the world of comics.
14 - The Cooper/Kripke Inversion
Outraged that he's being forced to work with his university nemesis, Barry Kripke (guest star JOHN ROSS BOWIE), Sheldon faces a crisis of conscience. Meanwhile, Howard and Raj spend a thousand dollars on action figures of themselves.
15 - The Spoiler Alert Segmentation
A fight between Leonard and Sheldon drives Leonard to finally move in with Penny - not realizing how the shift will affect Penny and Amy's living arrangements. Meanwhile, Raj takes care of Mrs. Wolowitz while Howard is away.
16 - The Tangible Affection Proof
While the guys try to give their significant others the perfect Valentine's Day, Raj and Stuart throw a lonely people party at the comic book store.
17 - The Monster Isolation
After a terrible date, Raj vows to never leave his apartment again. Meanwhile, Penny actually impresses Sheldon with her acting skills.
18 - The Contractual Obligation Implementation
Back to school! Leonard, Sheldon and Howard try to advance the cause of women in science by speaking with junior high girls about their future careers, while Raj plans his date with Lucy (guest star KATE MICUCCI).
19 - The Closet Reconfiguration
When Howard finds a letter from his father, he's forced to confront his past, struggling with whether or not he should open it. And Leonard and Penny throw a "grown-up" cocktail party at the apartment.
20 - The Tenure Turbulence
Let the battle begin! Leonard, Sheldon and Raj fight for tenure at the University - and the competition heats up when the girls get involved!
21 - The Closure Alternative
Sheldon feels lost after one of his favorite TV shows gets canceled too soon, so Amy tries to help him get over his compulsive need for closure. Meanwhile, Raj discovers a secret about his new love interest, Lucy.
22 - The Proton Resurgence
Sheldon and Leonard hire Professor Proton (guest star BOB NEWHART), the host of their favorite childhood TV show, to perform. Also, Howard and Bernadette run into trouble babysitting Raj's dog.
23 - The Love Spell Potential
When the girls' trip to Vegas falls through, the guys invite them to play Dungeons & Dragons- causing Sheldon and Amy's relationship to take an unexpected turn. Meanwhile, Raj and Lucy go on a very awkward date.
24 - The Bon Voyage Reaction
When Leonard is offered an exciting new job opportunity overseas, Sheldon grows very jealous and Penny is thrown for a loop. Meanwhile, Raj pushes Lucy a little too far in their relationship on the sixth season finale.
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