In the tradition of interweaving character drama and the supernatural in such hits as Smallville, a completely new kind of thrill ride takes viewers on a journey into the dark world of the unexplained in Supernatural. Bound by tragedy and blood to a dangerous, otherworldly mission, two brothers travel from the Colorado wilderness to the Nebraska farmlands and on to the isolated Wisconsin lakes, encountering creatures that most people believe only exist in folklore, superstition and nightmares.
01 - Pilot
Sam Winchester (series star JARED PADALECKI) has done his best to escape his family's eerie history. Unlike his older brother, Dean (series star JENSEN ACKLES), Sam rejected their father's obsessive quest to uncover the evil forces that claimed the life of the boys' mother. Putting as much distance as possible between himself and his family, Sam left home right after high school and went away to college. His new life includes a beautiful and loving girlfriend and plans to enter law school. Dean, however, took a very different path, following their father into the "family business". When Dean arrives on Sam's doorstep with the news that their father has vanished, Sam has no choice but to put his personal plans on hold and join Dean on the road.
After four years apart, the reunited brothers are getting to know each other again, and their familiar sibling rivalries are never far from the surface. Despite the strange childhood they shared, these boys turned out to have very different views of the world. Dean still idolizes his father and, although he often appears cocky and fearless, in reality he is haunted by memories of his mother's violent death. Sam was too young to remember the awful night that their mother died and has never fully accepted the frightening path his father and brother have followed.
A mysterious phone message from their father leads the Winchester brothers to a California town plagued by a series of unexplained deaths. They soon come face-to-face with the local legend of a Lady in White - a ghostly and beautiful hitchhiker who wanders country roads by night, luring young men to their doom. Although they don't find their father, Dean and Sam discover his journal and try to decipher his writings for clues that will help them destroy the spirit.
Once the job is done, Sam tries to return to college life but finds that the malevolent force that claimed his mother has now taken his girlfriend in the same unthinkable way. Fuelled by rage, sorrow and guilt, Sam suddenly understands his father's obsession. Like Dean, Sam is now totally committed to the hunt for answers and, ultimately, for revenge.
02 - Wendigo
Sam and Dean follow the coordinates left in their father's journal and land in the middle of the Colorado woods where they investigate the disappearance of several campers. The two brothers soon learn that they are dealing with a Wendigo, a creature made famous in Native American legends. A Wendigo is a former human whose cannibalism has transformed him into a creature with superhuman strength and speed.
03 - Dead in the Water
In a small town in Wisconsin, Sam and Dean investigate a series of mysterious drownings officially explained as suicides. They discover that the spirit of an angry little boy with the power to travel through water is taking revenge on certain town inhabitants for a dark secret buried long ago. Dean forms a bond with another young boy who seems to have the power of premonition.
04 - Phantom Traveler
On TransNational flight 2485, a man possessed by the spirit of the Phantom Traveler causes the plane to crash, leaving only five survivors. Sam and Dean must exorcise the angry spirit before it attacks the survivors. The brothers realize the only way to vanquish the Phantom Traveler is to battle it on another flight.
05 - Bloody Mary
In suburban Nebraska, several partying high school teens jokingly dare their friend Charlie (MARNETTE PATTERSON) to look into a mirror and repeat "Bloody Mary, Bloody Mary, Bloody Mary", not knowing that this will unleash a series of mysterious murders. Sam and Dean realize that Bloody Mary has the power to travel through all reflective surfaces when she is hunting a victim. Worried that teens are accidentally summoning Bloody Mary, Sam and Dean race to destroy the violent spirit before she can kill again.
06 - Skin
Sam and Dean help Sam's old college buddy after he is accused of a murder he swears he didn't commit. The brothers discover a shape-shifter is adopting the likenesses of others and murdering people. The brothers' race to stop the killing spree takes a terrifying turn when the shape-shifter morphs into the likeness of Dean.
07 - Hook Man
In a small college town in Iowa, Sam and Dean encounter the infamous "Hook Man", a vengeful spirit who kills his victims with a shiny hook that serves as his hand. Sam and Dean learn that all the victims are connected to the daughter of a local minister. They race to find and destroy the Hook Man's bones before he comes after them.
08 - Bugs
After a construction worker is killed by insects burrowing into his brain, Sam and Dean investigate a town's history and find that the new housing development is being built on sacred American Indian land. The Native Americans put a curse on the land after their reservation was ravaged and destroyed. Sam and Dean must find a way to survive and kill the deadly swarm of bees, locusts, spiders and beetles.
09 - Home
Sam is haunted by a vision of a woman trapped in the brothers' childhood house and convinces a reluctant Dean that they need to go home. Upon arrival, they meet the woman in Sam's premonition, and she reveals that the house is haunted. The brothers discover that their father visited a psychic, Missouri Mosley (LORETTA DEVINE - "Waiting to Exhale", "Crash"), after their mother's death, and they seek insight from the same woman. Together, the three discover that a malevolent poltergeist has inhabited the house and set out to exorcise it but are blindsided when another unseen spirit steps in.
10 - Asylum
Sam and Dean investigate an abandoned sanitarium and discover that the patients had held a revolt against the cruel and unusual punishments inflicted by the head doctor. While the brothers search the premises for four lost college students, the tortured spirits cause Dean and Sam to go insane, turning the brothers against each other.
11 - Scarecrow
Sam and Dean finally make contact with their father, but he tells them to stop looking for him and sends them on another ghost-hunting job. Frustrated with their father's evasiveness, Sam sets out alone to find him while Dean obeys his father and stays. Dean investigates a small town in Indiana where couples have gone missing the same day each year and discovers the farmers are sacrificing them to a pagan god who takes the form of a scarecrow. While en route to California, Sam meets Meg (recurring guest star NICKI AYCOX), a young backpacker, who unbeknownst to Sam is working for a demon.
12 - Faith
While battling a demon, Dean is electrocuted, resulting in permanent damage to his heart and leaving him with only a couple of months to live. A despondent Sam searches desperately for a way to save his brother and believes he may have found an answer through a preacher who claims to heal the incurable. However, Dean and Sam discover that the preacher is getting help from the Grim Reaper, who is trading one life for another he feels is less worthy.
13 - Route 666
Dean is contacted by his first love, Cassie (recurring guest star MEGALYN ECHIKUNWOKE), an African-American girl who asks him to come to Mississippi to investigate a string of racially motivated murders. Each murder is linked to a mysterious truck that seems to have no driver and leave no tracks. Sam is stunned to see this new side of his brother as Dean struggles to come to grips with the residual feelings he has for Cassie.
14 - Nightmare
Sam has a premonition in which a man is killed, but the murder is made to look like a suicide. Sam convinces Dean that they must investigate the case, but the two are puzzled when they fail to find anything that indicates that the death was supernatural in nature - that is, until they find out that Max (BRENDAN FLETCHER), the reclusive son of the first victim, has been using his recently acquired power of telekinesis to kill the family members that once abused him. Sam also discovers that Max's mother was killed by the same fiery demon that took Sam and Dean's mom.
15 - The Benders
Sam and Dean head to Minnesota where a young boy witnesses a man vanishing into thin air. While searching for clues, Sam is abducted by what he assumes is a supernatural being, and Dean is left to search frantically for his brother. However, both are stunned when they realize the kidnappers are human and are using the captives as human prey for a twisted hunting expedition.
16 - Shadow
While investigating a mysterious death in Chicago, Sam and Dean run into Meg (recurring guest star NICKI AYCOX), who is thrilled to see Sam again. But the brothers soon discover that Meg is responsible for several murders and attempt to catch her. Unfortunately, Meg remains one step ahead of them and unleashes shadow spirits to ambush the brothers. Sam and Dean ultimately realize the trap isn't for them but for their father, John (recurring guest star JEFFREY DEAN MORGAN).
17 - Hell House
Sam and Dean investigate a house haunted by the ghost of a man who killed his six daughters during the 1930s. The brothers discover a web site dedicated to the legend and realize the town is unknowingly conjuring up the evil spirit through the site.
18 - Something Wicked
Sam and Dean investigate a small town in Wisconsin where children are falling into comas for no apparent reason. The brothers discover that a witch is creeping into the bedrooms of the children and stealing their "life force". While battling the witch, Dean recalls a past mistake that almost cost Sam his life at the hands of the very same witch, an event that has fueled Dean's protectiveness over Sam and his blind obedience to his father.
19 - Provenance
A young husband and wife are killed in their home shortly after buying an antique painting of a family portrait from around 1910. Upon reviewing the painting's history of ownership, Sam and Dean learn that everyone who has ever bought it has been murdered, and they race to discover how the portrait is causing the deaths before it can claim its next victim.
20 - Dead Man's Blood
After a vampire hunter who was John's (recurring guest star JEFFREY DEAN MORGAN) mentor is murdered, Sam and Dean are surprised when John himself shows up to solve the case. When John discovers that vampires have stolen an antique gun that has the power to kill all supernatural beings, the Winchester family sets out to retrieve the weapon so they can destroy the demon that took Sam and Dean's mother.
21 - Salvation
After Sam has a vision of a family being attacked in the same manner as his mom was, the brothers and their father, John (recurring guest star JEFFREY DEAN MORGAN), head to Salvation, Iowa, to save the family Sam dreamed of and finally kill the demon using the antique gun they recently acquired. However, Meg (recurring guest star NICKI AYCOX) warns that she will start killing the Winchesters' friends unless they return the gun. John meets Meg to deliver a fake gun while the boys are left to deal with the demon.
22 - Devil's Trap
On a mission to save their father, John (recurring guest star JEFFREY DEAN MORGAN), from Meg (recurring guest star NICKI AYCOX), Sam and Dean seek help from an old family friend, Bobby (JIM BEAVER). When Meg shows up on Bobby's doorstep, the brothers lure her into a trap and exorcise the demon from her body after learning where John is being held prisoner. During the rescue attempt, a major battle ensues between the Winchesters and the demon they have been searching for all their lives.